Update 4: Jeff Atwood costs out Markus' scale up approach against a scale out approach and finds scale up wanting. The discussion in the comments is as interesting as the article. My guess is Markus doesn't want to rewrite his software to work across a scale out cluster so even if it's more expensive scale up works better for his needs.
Update 3: POF now has 200 million images and serves 10,000 images served per second. They'll be moving to a 250,000 IOPS RamSan to handle the load. Also upgraded to a core database machine with 512 GB of RAM, 32 CPU’s, SQLServer 2008 and Windows 2008.
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